Development Of Hydroxyapatite/Chitosan Composite Powder Via Mechanical Milling Method

Mohd Safuan, Anuar (2012) Development Of Hydroxyapatite/Chitosan Composite Powder Via Mechanical Milling Method. Project Report. UTeM, Melaka, Malaysia. (Submitted)

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Abstract

Hydroxyapatite (HA) is a calcium phosphate based ceramic that has been used for over 20 years in medicine and dentistry. The chemical composition of HA materials is same like bone tissue’s inorganic constituent and its mechanical properties are similar to mineral bone. Still, the use of HA made prosthesis supports only lighter loads as it is fragile. So it is important to enhance the mechanical properties of HA without affecting its biological, biocompatibility and ostreoconductive nature. For this purpose it is important to entrap the HA with biopolymeric material so that it can be used as a superior replacement for bone and also can be used as bone filler material. Among organic polymers, Chitosan (CS) has attractive features as bone substitute such as low toxicity, biodegradability and high flexibility. In this study, a mixture powder of HA/CS will be conducted using mechanical milling process to produce homogenize HA/CS composite powder. The concentration of CS filler added to the HA powder are 5, 10 and 20 wt.%. The effect of CS concentration in HA were investigated using XRD for phase analysis and the mechanical properties such as hardness, density and compressive strength were evaluated by Vickers microhardness, density and compression testing. In XRD analysis, HA and CS phase is still exist after the sintering process and for mechanical testing the optimum microhardness and density were represented by HA-20 wt.% CS. However, under compressive strength HA-5 wt.% CS recorded the best result compared to others composite composition

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