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Effect Of Polymeric Coating On The In-Vitro Degradation Of The Bioactive Tricalcium Phosphate Scaffold

Mustafa, Zaleha and Mohamad Juoi, Jariah and Othman, Radzali and Nam, Noor Akmar and Sheikh Md Fadzullah, Siti Hajar and Ishak, Nurfatiha (2017) Effect Of Polymeric Coating On The In-Vitro Degradation Of The Bioactive Tricalcium Phosphate Scaffold. Project Report. UTeM, Melaka, Malaysia. (Submitted)

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Abstract

TCP) have been studied in vitro. Porous β-TCP scaffolds have been prepared using a template method and sintered at, 1400, 1450 and 1500 °C maximum sintering temperatures. Preliminary work indicated an increase in the crystallinity of the β-TCP phase as the temperature was increased and no additional phase was identified. Morphological analyses revealed that an interconnected pore structure was successfully produced at all sintering temperatures. The scaffold struts surface appeared to be more dense with less cracks and voids with an increase of sintering temperature suggesting that better diffusion was achieved between the β-TCP particles at 1500°C. The bioceramics were then coated with PHBV solution before 6 weeks immersion in simulated body fluid (SBF) at 37°C. At the end of the immersion time, the scaffold showed insignificant changes in the SBF pH value, suggesting good stability against hydrolytic degradation. X-ray Diffraction (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) analysis revealed the presence of apatite. Morphology analysis by SEM showed the formation of apatite crystals in the form of flakes and globular depositions on the scaffold surface. This bone-like apatite indicates good biological activity of the bioceramics scaffold with PHVB coating The in-vitro immersion has been continue for further up to 24 weeks. The mechanical testing was carried out at each interval week to evaluate their mechanical performance. Both of the scaffold produced by in-house TCP and commercial TCP was evaluate. It was observed that scaffold was able to retain their original strength up to 8 weeks before slowly deteriorate. This suggesting that the composite has potential for bone tissue engineering applications.

Item Type: Final Year Project (Project Report)
Uncontrolled Keywords: Polymeric composites
Subjects: T Technology > T Technology (General)
T Technology > TA Engineering (General). Civil engineering (General)
Divisions: Library > Long/ Short Term Research > FKP
Depositing User: Mohd Hannif Jamaludin
Date Deposited: 23 Nov 2018 07:10
Last Modified: 23 Nov 2018 07:10
URI: http://digitalcollection.utem.edu.my/id/eprint/22318

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