Design of Biosensor using COMSOL Multiphysics

Rajendran, Sagundalai (2021) Design of Biosensor using COMSOL Multiphysics. Project Report. Universiti Teknikal Malaysia Melaka, Melaka, Malaysia. (Submitted)

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Abstract

LFBs (lateral flow biosensors) are dominant in biology and medicine, agricultural sectors, culinary, and geoscience because of their cheap rate, accessibility, speed, durability, and mobility. Nowadays, Computer simulation have been an important component of biosensor development. Lately, the COMSOL Multiphysics Simulation has shown to be a powerful virtualization technology, especially in Nanotechnology and, more crucially, in biomedical applications and other activities require fluid and solid processes. The research started with a simulation of a gold nanoparticle-based biosensor created with the COMSOL Multiphysics software package. The simulation was used to describe overall amplitude of something like the turbulent concentration’s gradient in the sample, speed area with in capillary streaming, fields related of adsorbate molecules, including averaged proportional surface coverage of absorbed analyte. Just after GNPs was simulated using Multiphysics, far radiation characteristics and thermal performance in gold nanoparticles were investigated. Subsequently, the polypeptide absorption is simulated, and the reactive component intensities vary over time. During five second and thirty seconds, the feature of enzyme B, as well as the velocity field, were discussed. The concentrations of proteins A and B are seen to change with the Gaussian concentration pulse feed inlet, also the behaviour of protein in which the bulk concentration is shown, indicate that the beads at the centre of the column are less accessible for adsorption or that the protein is more rapidly adsorbed at the centre, both phenomena lowering the bulk concentration there. and the velocity field that the porous structure causes a quite distorted velocity field. The exception is at the walls where the 76 flow is less obstructed due to the relatively large gap between beads and wall all of above to increase the accuracy of magnitude of the laminar velocity field in the flow cell, concentration distribution in the analyte stream and surface coverage of adsorbed species and Average fractional surface coverage of adsorbed analyte concerned in biosensor model based on gold nanoparticles GNPS in Multiphysics.

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