Synthesis of calcium phosphate from local fish bone for biomedical application

Mohd Zafri, Mazatul Nadia (2018) Synthesis of calcium phosphate from local fish bone for biomedical application. Project Report. Universiti Teknikal Malaysia Melaka, Melaka, Malaysia. (Submitted)

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Abstract

Hydroxyapatite (HA) is one of the biomaterials which is widely used in various fields for multiple biomedical and clinical application. Hydroxyapatite is mostly implemented into medical devices as bone graft or joint replacement. Basically, HA is obtained by extraction process which involved the bio waste of few resources such as fish bones, fish scales, and animal bones. In this study the HA was synthesized from the fish bones collected from the local area. The synthesizing process of HA was done via simple heat treatment by calcination at different temperature ranging from 600 °C to 1000 °C. The as-synthesized HA then were used to form dense body using the uniaxial pressing method and sintered at 1250°C. XRD analysis shows that the major phase was HA in all powders. Moreover, the intensity of HA powder obtained by treated by calcination at various temperature was increased as the temperature increased. However, as the temperature was increased more than 800°C, the HA peaks become less intense and broader as HA might transform to other phase; tri-calcium phosphate. SEM reveals that the HA powders were formed by agglomeration of small particles. Sintering at 1250 °C resulted in the decomposition of HA to TCP. The hardness analysis shows that the hardness of dense HA was increased as the calcination temperature to produce HA from fish bone was increased. This study reveal that the property of the initial HA powder which produce from fish bone calcined at different temperature played a significant role for the property of dense HA.

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