Resting State EEG Current Source Density Of Neural Oscillation:A Comparison Between Schizophrenia Patients And Healthy Controls

Suhamey, Nurmazila (2017) Resting State EEG Current Source Density Of Neural Oscillation:A Comparison Between Schizophrenia Patients And Healthy Controls. Project Report. Universiti Teknikal Malaysia Melaka, Melaka, Malaysia. (Submitted)

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Abstract

The aim of our study was to detect changes in the distribution of electrical brain activity in schizophrenia patients compared to healthy controls.15 patients with Schizophrenia (nine males;mean age ± standard deviation,32.00 ± 9.38) and 15 matched healthy controls (nine males;mean age ± standard deviation,32.65 ± 9.78 years) provided written informed consent and were enrolled in this study.Continuous EEG activity was recorded using Ag/AgCl electrodes mounted in a 64 channel actiCAP system (Brain Products,Munich,Germany).The frequency band that involves is delta (1.5-6 Hz),theta (6-8 Hz), alpha (8-12 Hz), and beta (12-30Hz).The objective of this project is to determine the EEG oscillation (frequency bands) that is significantly different between patients and healthy control and to determine the brain region that is responsible for the differences.Firstly,pre - processing will be done by filtering,down sampling,manual artifact detection to remove muscle artifact and artifact detection - using independent component analysis (ICA) to remove eye -blink and heartbeat,re-referencing and baseline correction. Next,the pre-processed data will be analyzed using Loreta software.Then,the oscillatory analysis will be conducted to determine the EEG oscillations (frequency bands) that are significantly different between patients and healthy controls.The results is show by comparing a schizophrenia patients and healthy controls,it was found a trend towards significant current density increase in the delta,theta,alpha,and beta frequency band.Lastly,the brain regions that are responsible for the differences at alpha and beta are cingulate gyrus (limbic lobe) and anterior cingulate (limbic lobe).

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